| Sysley | One who dwells in the meadow. |
| Syssota | A name meaning star of heaven. |
| Szandra | Protector of Humanity |
| Szilvia | One who lives in the woods. |
| Szonja | A name meaning wise and gifted. |
| Saanika | A name meaning flute or melody. |
| Sacaja | A name meaning bird woman. |
| Sacajawea | Known as the bird woman guide. |
| Saeng | A name meaning light or glow. |
| Sagaia | A name meaning wise traveler. |
| Sahasi | One who is brave and courageous. |
| Samosa | A fried pastry with filling. |
| Samskriti | Refers to culture or tradition. |
| Samudri | One related to the vast ocean. |
| Samui | Derived from the word for safe. |
| Sanae | A name meaning early rice. |
| Sanaia | God has spoken to the soul. |
| Santorini | Saint Irene of Thera. |
| Saraah | A name meaning pure or joy. |
| Sardinia | Named after the ancient Sardi tribe. |
| Sargami | One who is skilled in music notes. |
| Sarpini | A term referring to a female snake. |
| Satet | An ancient Egyptian goddess of Nile. |
| Satyajita | One who is victorious in the truth. |
| Saurabhi | A name meaning celestial fragrance. |
| Scathach | A legendary warrior woman. |
| Scheana | A name meaning God is kind. |
| Securitas | The Roman goddess of security. |
| Sedna | Inuit goddess of the deep sea. |
| Seia | Roman goddess of sown seeds. |
| Sekhmet | Egyptian goddess of war. |
| Selket | Egyptian goddess of healing. |
| Selkie | A mythical sealfolk creature. |
| Selyse | A name meaning noble or kind. |
| Sentia | Derived from the Latin word for feeling. |
| Senua | Ancient name linked to a Celtic deity. |
| Septa | A term referring to a partition wall. |
| Serama | A small breed of ornamental chicken. |
| Sereia | The Portuguese word for a mermaid. |
| Serein | Fine rain falling from a clear sky. |